Response to imatinib in villonodular pigmented synovitis (PVNS) resistant to nilotinib

Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT).

letters to the editor Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT) Pigmented villonodular synovitis (PVNS), also known as tenosynovial giant cell tumor (TGCT), is a rare pathological entity affecting the synovium in young adults [1, 2]. Initially considered as an inflammatory reactive process, recent observations have show...

Pigmented villonodular synovitis responsive to imatinib therapy.

I n 2002 when he was 27 years old, our patient sought care for a 2-year history of right hip pain that he fi rst noted after jogging. Th e pain progressed to where he could not run. He saw his family practitioner, who thought it might be a hernia. Later, the pain progressed, and he was referred to an orthopaedic surgeon. He was referred to Baylor University Medical Center at Dallas for further ...

Pigmented villonodular synovitis.

Pigmented villonodular synovitis.

Pigmented villonodular synovitis (PVS) is an uncommon, usually monoarticular disorder encountered mainly in adults. A boy and a girl, both 7 years old, were referred because of recurrent knee effusions. Both were medically treated for other rheumatic disorders for five years. PVS was diagnosed by arthroscopy and synovectomy was curative in both cases.

Successful treatment of relapsing Pigmented Villonodular Synovitis (PVNS) of the knee with radiosynoviorthesis

PVNS is a rare disorder characterised by benign proliferation of synovial tissue. The treatment is surgical but relapse rate is high (8% to 46%). We report a 13 years old girl with PVNS of the left knee diagnosed in February 2003. Three months after diagnosis she underwent surgical synovectomy. Two years later important swelling of left knee with pain and limitation of movement developed and MR...